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Seven guests, a newly hired personal secretary and two staff are gathered for a weekend on an isolated island by the hosts, the Owens, who are delayed. At dinner, a record is played and the hosts message alleges that all of the people present are guilty of murder, and suddenly the first of them is dead, then the next. It seems that one of them is the murderer, but the leading person is always the person who is murdered next and at last, only two people are left.
Judge Francis J. Quincannon (Barry Fitzgerald), Dr. Edward G. Armstrong (Walter Huston), Philip Lombard (Louis Hayward), Detective William Henry Blore (Roland Young), the newly hired secretary Vera Claythorne (June Duprez), Prince Nikita Starloff (Mischa Auer), General Sir John Mandrake (C. Aubrey Smith), and Emily Brent (Dame Judith Anderson) are invited by the mysterious hosts, the Owens, to spend the weekend on an isolated island and they are met by the recently hired butler Thomas Rogers (Richard Haydn) and his wife and housekeeper Ethel Rogers (Queenie Leonard). Thomas explains that the Owens will arrive later and following the instructions of his employer, he plays a record where the hosts message explains that all of them have been summoned because they are guilty of murder. The ten realize that none of them has actually met their hosts. Vera recites the poem about Ten Little Indians when they notice a centerpiece on the table with ten Indian figures. Soon they are killed off one-by-one, and each time one of the Indian figurines is destroyed. Are they guilty of a murder, and who is the the mysterious killer on the island?
Barry Fitzgerald
Judge Francis J. Quincannon
Walter Huston
Dr. Edward G. Armstrong
Louis Hayward
Philip Lombard
Roland Young
Detective William Henry Blore
June Duprez
Vera Claythorne
Mischa Auer
Prince Nikita Starloff
C. Aubrey Smith
Gen. Sir John Mandrake
Judith Anderson
Emily Brent
Richard Haydn
Thomas Rogers
Queenie Leonard
Ethel Rogers
Harry Thurston
Fred Narracott
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