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With Charlie Chan distracted by the imminent birth of his first grandchild, young Tommy Chan persuades his older brother Jimmy (eager to be a detective) to take Pops place when a call comes in directing Charlie to investigate a murder aboard a freighter. Charlie eventually learns of this and boards the ship to straighten out its slew of suspects, a cargo hold full of wild animals, and two well-meaning but ineffectual sons.
When murder is committed on the good ship Susan B Jennings, Charlie has just left home. Young son Tommy takes the phone call when Charlie is assigned the case and persuades elder brother Jimmy (who wants to be a detective) to accept the assignment. Jimmy goes out to the ship himself (secretly followed by Tommy), where hes mistaken for his father as he proceeds to examine the case. Charlie finally finds out and rushes to the harbor where he straightens things out and begins to investigate. Among the suspects is a doctor who keeps a living human brain in a suitcase in order to continue experiments on it, a police detective who is taking in a prisoner and seems keenly interested in Chans case, and a nervous fellow who nevertheless is escorting a pet lion. $300,000 gets stolen, another passenger is murdered, and the Captain of the freighter is putting pressure on the Honolulu Police Department to let him take the ship out of the harbor and precede on its way before the shipping company loses too much money.
Sidney Toler
Charlie Chan
Phyllis Brooks
Judy Hayes
Victor Sen Yung
James Chan
Eddie Collins
Al Hogan
John 'Dusty' King
George Randolph
Claire Dodd
Carol Wayne
George Zucco
Dr. Cardigan
Robert Barrat
Capt. Johnson
Marc Lawrence
Johnny McCoy
Richard Lane
Joe Arnold
Layne Tom Jr.
Tommy Chan
Philip Ahn
Wing Foo
Paul Harvey
Police Inspector Rawlins
Richard Alexander
Crewman
Martin Cichy
Crewman
Ruth Clifford
Nurse
David Dong
Chan Son
James Flavin
Homicide Division Desk Sergeant
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