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After losing Vanessa (Morena Baccarin), the love of his life, 4th-wall breaking mercenary Wade Wilson aka Deadpool (Ryan Reynolds) must assemble a team and protect a young, fat mutant Russell Collins aka Firefist (Julian Dennison) from Cable (Josh Brolin), a no-nonsense, dangerous cyborg from the future, and must also learn the most important lesson of all: to be part of a family again.
After successfully working as the mercenary Deadpool for two years, Wade Wilson fails to kill one of his targets on his anniversary with Vanessa, his girlfriend. That night, after the pair decide to start a family together, the target tracks Wilson down and kills Vanessa. Wilson kills the man in revenge. He blames himself for her death and attempts to commit suicide six weeks later by blowing himself up. Wilson has a vision of Vanessa in the afterlife, but the pieces of his body remain alive and are put back together by Colossus. Wilson is left with only a Skee-Ball token, an anniversary gift, as a final memento of Vanessa. Recovering at the X-Mansion, Wilson reluctantly agrees to join the X-Men as a form of healing. He, Colossus, and Negasonic Teenage Warhead respond to a standoff between authorities and the unstable young mutant Russell Collins / Firefist at an orphanage, labeled a "Mutant Reeducation Center"..
Ryan Reynolds
Wade Wilson
Josh Brolin
Cable
Morena Baccarin
Vanessa
Julian Dennison
Firefist
Zazie Beetz
Domino
T.J. Miller
Weasel
Leslie Uggams
Blind Al
Karan Soni
Dopinder
Brianna Hildebrand
Negasonic Teenage Warhead
Jack Kesy
Black Tom
Eddie Marsan
Headmaster
Shioli Kutsuna
Yukio
Stefan Kapicic
Colossus
Randal Reeder
Buck
Nikolai Witschl
Head Orderly Frye
Thayr Harris
Sergei Valishnikov
Rob Delaney
Peter
Lewis Tan
Shatterstar
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