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Housewife Roberta Glass of Fort Lee, New Jersey, is feeling restless in her life, where she has not taken any chances, including in her marriage to home spa retailer Gary Glass, who knows what to expect in her every move, and who is more concerned about his public image with respect to his business than her. If being honest, Gary would consider her uptight. She does have a few diversions, one of her favorite being reading the personal classifieds, most specifically those written by someone named Jim whose ads are always titled "Desperately Seeking Susan". Roberta gleans that Jim and Susan are in a relationship of sorts with the ads the only way for him to get in touch with her as she travels around the country. Obsessed with the pair, Roberta decides to go to Battery Park when the latest ad requests Susan meet Jim there. In her sighting from afar, Roberta can see that Susan is a wild, new wavish attired woman, to some extent a polar opposite to Roberta herself. Out of circumstance, Roberta is able to purchase Susans easily identifiable leather jacket from a third party, which in the process leads to Roberta getting amnesia, further resulting in her being able to obtain all of Susans personal possessions, making her believe that she must be who these possessions point to her being. This causes some confusion for Dez, a friend of Jims who has never met Susan, and who Jim, a rock musician, asked to look after Susan in his needed absence out of town for a gig. Dez, a movie projectionist, cant help but fall for Roberta who he believes is Susan, while Roberta, in her newfound freedom, falls for Dez in return. What Roberta is unaware of, even before her amnesia, is that a criminal, Wayne Nolan, who has already killed once, is after Susan with regard to some priceless Egyptian earrings Susan has out of circumstance, he only knowing her from that iconic leather jacket. Susan does eventually learn this information about Wayne and thus tries to track down this mysterious woman who has stolen her possessions both to get back her stuff but also warn her about Wayne. Matters will only get more complicated as Gary gets closer to tracking down his missing wife, when Jim comes back into town looking for Susan, and if and when Roberta regains her memory.
Roberta Glass is a housewife, bored with her life and feeling ignored by her husband, a hot tub salesman. The one thing that interests her is the excitement and romance she finds in following the relationship of Jim and Susan, who communicate through their travels using the personal ads. A mysterious drifter, Susan leads the kind of free-spirited life about which Roberta can only dream. Susan is having her own fun when she sees the personal ad to meet Jim in New York City. Unfortunately, Susan is unaware that the last man she was with is entangled with the mob. So when Roberta shows up to actually see her idol, she takes it upon herself to emulate her. After a bout of amnesia, she is mistaken for Susan and must survive with Susan, Jim, her husband, and the mob - scrambling for the truth.
Rosanna Arquette
Roberta Glass
Madonna
Susan
Aidan Quinn
Dez
Mark Blum
Gary Glass
Robert Joy
Jim
Laurie Metcalf
Leslie Glass
Anna Thomson
Crystal
Will Patton
Wayne Nolan
Peter Maloney
Ian
Steven Wright
Larry Stillman D.D.S
John Turturro
Ray
Anne Carlisle
Victoria
José Angel Santana
Boutique Owner
Giancarlo Esposito
Street Vendor
Richard Hell
Bruce Meeker
Rockets Redglare
Taxi Driver
Steve Bosh
Newscaster
Daisy Bradford
Daisy
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