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While Gru, the ex-supervillain is adjusting to family life and an attempted honest living in the jam business, a secret Arctic laboratory is stolen. The Anti-Villain League decides it needs an insiders help and recruits Gru in the investigation. Together with the eccentric AVL agent, Lucy Wilde, Gru concludes that his prime suspect is the presumed dead supervillain, El Macho, whose his teenage son is also making the moves on his eldest daughter, Margo. Seemingly blinded by his overprotectiveness of his children and his growing mutual attraction to Lucy, Gru seems on the wrong track even as his minions are being quietly kidnapped en masse for some malevolent purpose.
The ex-villain Gru is raising his daughters Margo, Edith and Agnes and researching a legitimate jelly and jam business with Dr. Nefarion and the minions. Meanwhile, a laboratory in Arctic is stolen by a powerful aircraft using magnetism. The Anti-Villain league (AVL) agent Lucy Wilde recruits Gru to help her agency discover who has stolen the laboratory and its research. They know that the thief has a store in a mall, and Gru suspects that the owner of the Mexican restaurant Salsa & Salsa, Eduardo Perez, may be the villain El Macho that is presumed dead.
Steve Carell
Gru
Kristen Wiig
Lucy
Benjamin Bratt
Eduardo Pérez
Miranda Cosgrove
Margo
Russell Brand
Dr. Nefario
Ken Jeong
Floyd Eagle-san
Steve Coogan
Silas Ramsbottom
Elsie Fisher
Agnes
Dana Gaier
Edith
Moises Arias
Antonio Pérez
Nasim Pedrad
Jillian
Kristen Schaal
Shannon
Pierre Coffin
Kevin the Minion
Chris Renaud
Additional Minions
Nickolai Stoilov
Arctic Lab Guards
Vanessa Bayer
Flight Attendant
Ava Acres
Additional Voices
Lori Alan
Additional Voices
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