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Paranormal researcher Abby Yates and physicist Erin Gilbert are trying to prove that ghosts exist in modern society. When strange apparitions appear in Manhattan, Gilbert and Yates turn to engineer Jillian Holtzmann for help. Also joining the team is Patty Tolan, a lifelong New Yorker who knows the city inside and out. Armed with proton packs and plenty of attitude, the four women prepare for an epic battle as more than 1,000 mischievous ghouls descend on Times Square.
Physicists Abby Yates and Erin Gilbert are authors of a research book which posits the existence of paranormal phenomena, such as ghosts. While Abby continued to study the paranormal at a technical college with eccentric engineer Jillian Holtzmann, Erin, now a professor at Columbia University, disowned the work, fearing it will impact her tenure. When Abby republishes the book, Erin convinces her to agree to remove the book from publication in exchange by helping Abby and Jillian in a paranormal investigation. They witness a malevolent ghost, restoring Erins belief in the paranormal, but video footage of the investigation is posted online, and Erin is fired by the university. She joins Abby and Jillian to set up new offices above a Chinese restaurant, calling themselves "Conductors of the Metaphysical Examination". They build equipment to study and capture ghosts, and hire the dimwitted but handsome Kevin Beckman as a receptionist..
Melissa McCarthy
Abby Yates
Kristen Wiig
Erin Gilbert
Kate McKinnon
Jillian Holtzmann
Leslie Jones
Patty Tolan
Zach Woods
Tour Guide Garrett
Ed Begley Jr.
Ed Mulgrave
Charles Dance
Harold Filmore
John Milhiser
Higgins Student
Ben Harris
Higgins Student
Karan Soni
Bennie
Bess Rous
Gertrude Aldridge Ghost
Steve Higgins
Dean
Neil Casey
Rowan North
Dave Allen
Electrocuted Ghost
Katie Dippold
Rental Agent
Chris Hemsworth
Kevin
Nate Corddry
Graffiti Artist
Daniel Ramis
Metal Head
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