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Will Ferrell
Sherlock Holmes
John C. Reilly
Dr. Watson
Ralph Fiennes
Professor James Moriarty
Rebecca Hall
Grace Hart
Rob Brydon
Inspector Lestrade
Kelly Macdonald
Mrs. Martha Hudson
Lauren Lapkus
Millicent
Pam Ferris
Queen Victoria
Hector Bateman-Harden
Young Holmes
Codie-Lei Eastick
Young Watson
Laura Stevely
Sherlock's Mom
Layla Rose Boyce
Nicotine Stains
Sadie Newman
Jane
Harry Baxendale
Seamus
Ella Bright
Bridgette
Kenneth Hadley
Headmaster
Paul Bigley
Teacher #1
Sue Maund
Teacher #2
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