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An outbreak of dog flu has spread through the city of Megasaki, Japan, and Mayor Kobayashi has demanded all dogs to be sent to Trash Island. On the island, a young boy named Atari sets out to find his lost dog, Spots, with the help of five other dogs... with many obstacles along the way.
As a nasty and extremely virulent canine flu ravages the technologically-advanced metropolis of Megasaki from end to end, the unscrupulous and corrupt mayor, Kobayashi, decrees that all dogs be banished to Trash Island--a vast offshore wasteland of refuse. To track down his beloved four-legged companion, Spots, Kobayashis courageous twelve-year-old orphaned nephew, Atari, summons up the courage to set off alone on a dangerous rescue mission; however, to reunite with his best friend, the boy will need the precious help of a marauding pack of five abandoned alpha dogs. But, who may know the whereabouts of Spots, the Isle of Dogs hapless prisoner zero?
Bryan Cranston
Chief
Koyu Rankin
Atari
Edward Norton
Rex
Bob Balaban
King
Jeff Goldblum
Duke
Bill Murray
Boss
Kunichi Nomura
Mayor Kobayashi
Akira Takayama
Major-Domo
Greta Gerwig
Tracy Walker
Frances McDormand
Interpreter Nelson
Akira Ito
Professor Watanabe
Scarlett Johansson
Nutmeg
Harvey Keitel
Gondo
F. Murray Abraham
Jupiter
Yoko Ono
Assistant-Scientist Yoko-ono
Tilda Swinton
Oracle
Ken Watanabe
Head Surgeon
Mari Natsuki
Auntie
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