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Dr. Aranya is experimenting with reciprocal transplants of pituitary glands between spiders and humans. The work is carried out in remote, underground labs located on the Zarpa Mesa in the Mexican desert. He wants to create a master race of hybrid superwomen and spiders through his procedures. He invites Dr. Leland Masterton, a famous entomological scientist, to see his creations. Masterton is horrified and subsequently becomes the next candidate for experimentation. The techniques work better on females than males. Masterton is released and is quickly institutionalized. More outsiders become involved with Dr. Aranya when a plane carrying the wealthy financier, Jan van Croft, and his bride to be, Doreen Culbertson, crashes on the mesa. Also aboard is Masterton, who has forced the pilot to fly the plane despite it being in need of engine repairs. The survivors are captured in hopes of using them for additional experiments. Masterton is determined to put an end to the experimentation. He mixes an explosive concoction and sends the pilot and Doreen down a side passage to escape. They get picked up by an oil company surveyor as they are about to perish of thirst and heat exposure.
Jackie Coogan
Dr. Aranya
Allan Nixon
'Doc' Tucker
Richard Travis
Dan Mulcahey
Lyle Talbot
Narrator
Paula Hill
Doreen Culbertson
Robert Knapp
Grant Phillips
Tandra Quinn
Tarantella
Chris-Pin Martin
Pepe
Harmon Stevens
Dr. Leland J. Masterson
Nico Lek
Jan van Croft
Kelly Drake
Lost Woman
John Martin
Frank
George Barrows
George
Candy Collins
Lost Woman
Dolores Fuller
Blonde 'Watcher in the Woods'
Dean Riesner
Aranya Henchman
Doris Lee Price
Lost Woman
Mona McKinnon
Lost Woman
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