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Having learned his lesson after the events of , meek, gentle Dr Sherman Klump dedicates himself to science. However, when Denise Gaines, a beautiful fellow DNA researcher, enters the picture, once more, Dr Klump is in love. And, as the love-smitten professor dreams of a brighter future, the lean-and-mean Buddy Love persona emerges, demanding freedom. Now, the nasty alter-ego stands in the way of happiness, and poor Sherman must do everything in his power to rid himself of Buddy once and for all. Can the rowdy Klump family lend a helping hand?
Professor Sherman Klump is getting married. And the Klump family could not be more delighted for him. But Buddy Love, his Mr. Hyde alter-ego from the first film, is back and trying to make it on his own. Buddy keeps resurfacing in untimely outbursts, and threatening the portly professors marriage plans to colleague Denise Gaines. Utilizing Denises cutting-edge DNA research, Sherman decides to rid himself of his monstrous nemesis -and his disruptive outbursts-once and for all by extracting Buddys DNA from his system. But Buddy bursts full-bodied into Shermans world and lays claim to the professors astounding invention - a revolutionary youth serum. Desperate to keep it from Buddy, Sherman hides the serum in the Klump family home, thinking it will be safe. Buddy correctly divines where Sherman has placed the serum, but to get it, he has to deal with the entire Klump family first.
Eddie Murphy
Sherman Klump
Janet Jackson
Denise
Larry Miller
Dean Richmond
John Ales
Jason
Richard Gant
Denise's Father
Anna Maria Horsford
Denise's Mother
Melinda McGraw
Leanne Guilford
Jamal Mixon
Ernie Klump, Jr.
Gabriel Williams
Isaac
Chris Elliott
Restaurant Manager
Duffy Taylor
Restaurant Trainee
Earl Boen
Dr. Knoll
Nikki Cox
Bright Student
Freda Payne
Claudine
Sylvester Jenkins
Old Willie
Wanda Sykes
Chantal
George King
Stripper
Charles Walker
Preacher
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