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Frank Detorre is a slovenly zookeeper and widowed father to his daughter, Shane. He catches a cold right after he swallows a germ-ridden egg. The inside of his body is known as the "City of Frank". An unlikely hero of a white blood cell named Osmosis Jones, works as a member of Immunity cell. But with that egg comes a mortal danger: Osmosis discovers that Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat his body, killing him from the inside out. Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous ones. His grandiose plan for Frank is death in 48 hours, breaking previous medical records. Meanwhile the cold pill that Frank took, Drix, arrives in the body and covers his throat with ice to cover the irritation. Osmosis becomes his newest partner. Now its all up to them to put an end of Thraxs plans before Frank dies and Shane becomes an orphan.
When zookeeper Frank, widowed father to his daughter, Shane, swallows a germ-ridden egg, he gives billions of lifeforms inside his body much work to do. In the "City of Frank", which has its good and bad neighborhoods, its own TV station, donut shops, and traffic jams, a white blood cell named Osmosis Jones is one of the many cops who try to keep up peace and order. Unfortunately, he seems to be the only cop in town who does not act by the book, but by his instincts. Even more unfortunately, they dont work out that often, and so he causes more trouble than he does good. But with that egg comes a mortal danger: the evil and deadly virus Thrax arrives in order to kill Frank within 48 hours, just to get his own chapter in the medical books. Starting out with flu symptoms in order to deceive the authorities and the public, he makes his way through Franks body. Accompanied only by "temporary relief of symptoms commonly associated with flu" cold tablet Drix, Osmosis suspects that there is more going on than just a simple flu. Meanwhile, Mayor Phlegmming is much more interested in his re-election than in real problems and tries to keep trouble down. So, it is up only to Osmosis and Drix to stop the "red death" from making Shane an orphan.
Laurence Fishburne
Thrax
Chris Rock
Osmosis Jones
David Hyde Pierce
Drix
Brandy Norwood
Leah
William Shatner
Mayor Phlegmming
Ron Howard
Tom Colonic
Kid Rock
Kidney Rock
Kenny Olson
Kidney Rock
Jason Krause
Kidney Rock
Joe C.
Kidney Rock
Stefanie Eulinberg
Kidney Rock
Jimmie Bones
Kidney Rock
Uncle Kracker
Kidney Rock
Jonathan Adams
Additional Character Voice
Carlos Alazraqui
Additional Character Voice
Keith Anthony
Additional Character Voice
Eddie Barth
Additional Character Voice
Sally Ann Brooks
Additional Character Voice
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