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With Dr. John Watson about to marry and end their partnership, a disconsolate Sherlock Holmes occupies his time investigating the schemes of his archenemy, Professor James Moriarty. However, when Moriarty warns that he considers the Watsons a legitimate target for his retaliation against the detective, Holmes must save them and get John involved in one last case. To do so, they join the Roma lady Madam Simza Herons quest to find her missing brother, Renee, who may be the key to defeating Moriarty. Together, the trio find themselves involved in a dangerous international conspiracy led by the Napoleon of Crime in which the fate of all of Europe hangs in the balance.
Sherlock Holmes is investigating terrorist attacks in London alone since his old partner Dr. John Watson will get married a few days later with Mary. His investigations point to Professor James Moriarty as the person responsible for the explosions. When Dr. Watson and Mary are attacked in the train while traveling for their honeymoon in Brighton, Holmes delivers Mary to the protection of his brother Mycroft. Soon Holmes and Dr. Watson disclose that Professor Moriarty has bought arms and ammunition factories and is trying to start a war in Europe killing political leaders and politicians. Now Sherlock and Watson have to stop Moriarty and his dangerous associate, the skilled former Colonel Sebastian Moran to avoid the imminent war.
Robert Downey Jr.
Sherlock Holmes
Jude Law
Dr. John Watson
Jared Harris
Professor James Moriarty
Rachel McAdams
Irene Adler
Noomi Rapace
Madam Simza Heron
Stephen Fry
Mycroft Holmes
Paul Anderson
Colonel Sebastian Moran
Kelly Reilly
Mary Watson
Geraldine James
Mrs. Hudson
Eddie Marsan
Inspector Lestrade
William Houston
Constable Clark
Wolf Kahler
Doctor Hoffmanstahl
Iain Mitchell
Auctioneer
Jack Laskey
Carruthers
Patricia Slater
Shush Club Maitre D'
Karima McAdams
Shush Club Maitre D'
Richard Cunningham
Businessman
Marcus Shakesheff
Hashisheen
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