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While practicing motocross in Hawaii, Sean Jones witnesses the brutal murder of an important American prosecutor by the powerful mobster Eddie Kim. FBI agent Neville Flynn persuades him to testify against Eddie in Los Angeles. They board the red-eye Flight 121 of Pacific Air, occupying the entire first-class section. However, Eddie dispatches hundred of different species of snakes airborne with a time-operated device in the luggage to release the snakes into the flight with the intent of crashing the plane. Neville and the passengers must struggle with the snakes to survive.
Neville Flynn escorts a witness onto a plane headed for Los Angeles. Problem is, an assassin bent on killing the witness has released a crate containing about 450 snakes onto the same plane. When Neville finds out, he determines to do his job and get the snakes back where they belong: on land. Or in snake heaven, where theyd be harmless. Can he get the snakes off the plane before its too late?
Samuel L. Jackson
Neville Flynn
Julianna Margulies
Claire Miller
Nathan Phillips
Sean Jones
Rachel Blanchard
Mercedes
Flex Alexander
Three G's
Kenan Thompson
Troy
Keith Dallas
Big Leroy
Lin Shaye
Grace
Bruce James
Ken
Sunny Mabrey
Tiffany
Casey Dubois
Curtis
Daniel Hogarth
Tommy
Gerard Plunkett
Paul
Terry Chen
Chen Leong
Elsa Pataky
Maria
Emily Holmes
Ashley
Tygh Runyan
Tyler
Mark Houghton
John Sanders
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