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Los Angeles based organic chemist Andrew Brewster has just sunk his life savings into developing and now marketing an environmentally friendly, effective and human safe home cleaning product. Despite these attributes, he is having problems making any sales to distributors and retailers. He has planned a cross country business trip via automobile to make sales pitches to various companies along the way, starting in New York City and ending in Las Vegas. While in New York, Andy plans to stay with his overbearing mother, New Jersey residing Joyce Brewster, with who he has a love/hate relationship and who he does not see very often anymore. He doesnt want to tell her of his sales failures thus far as he knows she will only add more than her two-cents into the matter, which he doesnt want. Joyces focus of attention is on Andys single status and what looks to be his stalled romantic life, out of which again he wants her to stay. Widowed when Andy was eight, Joyce has never remarried or dated for that matter, she not wanting to go through the trouble of a critical eye of another person in her life. Andy wishes she would make an effort with men both to make her happy and so that she will focus on her own life instead of his. When Joyce makes a revelation about her past love life to Andy just before he is ready to depart from New Jersey, Andy decides to invite Joyce along on the trip, making a final stop in San Francisco to revisit that past without telling her the reason. Joyce accepts. Through the ups and downs of their trip, Andy and Joyce may come to a better understanding of their relationship, Andys business failures, and what is needed to move on with their lives as happy, productive people.
Andy Brewster (Seth Rogen) is a UCLA-graduate organic chemist and inventor. He is attempting to get his environmentally friendly cleaning product, ScieoClean, in a major retail store. However, each retail store he visits dismisses him before he can end his pitch. After a disappointing sales pitch to K-Mart, he visits his mother, Joyce Brewster (Barbra Streisand), in New Jersey before leaving on a cross-country trip to Las Vegas, lying to her that his pitch ended well so she wont worry about him. While there she reveals to him that he was named after a boy she fell in love with in Florida named Andrew Margolis, whom she hoped would object to her marriage with Andys father. However, he never did and she felt that she never mattered to him afterwards. After a little research, he finds Andrew Margolis is still alive and unmarried living in San Francisco. He invites his unknowing mother on the trip, claiming he wants to spend some time with her.
Barbra Streisand
Joyce Brewster
Seth Rogen
Andrew Brewster
Julene Renee
K-Mart Receptionist
Zabryna Guevara
K-Mart Executive
John Funk
K-Mart Executive
Robert Curtis Brown
K-Mart Executive
Kathy Najimy
Gayle
Miriam Margolyes
Anita
Rose Abdoo
Diana
Tom Virtue
Mature Singles Man
Vivian Vanderwerd
Mature Singles Woman
Worth Howe
Bob
Vicki Goldsmith
Young Joyce
Matthew Levinson
Toddler Andy
Joseph Levinson
Toddler Andy
Kevin O'Keefe
Budget Car Renter
Rick Gonzalez
Mark
Jeff Witzke
Middlesex Voice Over
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