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When a bottle containing a plea for help from a little girl named Penny makes its way to the Rescue Aid Society, a mouse organization in the basement of the United Nations building dedicated to the rescue and well-being of anyone in need, it is up to the brave mouse Miss Bianca and her chosen partner, the shy janitor Bernard, to rescue the girl. Searching for clues at Pennys home at Morningside Orphanage in New York City, the two mice discover that the girl has been kidnapped by the evil pawn shop owner Madame Medusa and her companion Mr. Snoops. On the back of Orville the albatross, Miss Bianca and Bernard travel to the terrifyingly gloomy Devils Bayou where they learn the shocking truth: the innocent young girl is being forced down into a dangerous, dark underground pirates cave where she must find the Devils Eye, the worlds largest diamond and Madame Medusas greatest obsession. Before returning safely home, Miss Bianca, Bernard, and Penny will have to combat Madame Medusas two ferocious pet alligators Brutus and Nero with the help of Ellie Mae and Evinrude the dragonfly, as well as survive the raging tides inside the horrible pirates cave.
Bernard and Bianca, of the Rescue Aid Society (a mouse organization) receive a message in a bottle from an orphaned girl who appears to have been kidnapped by Madame Medusa, a selfish woman who has no qualms about using children for her own purposes. The two mice go off to Devils Bayou to attempt to rescue the little girl.
Bob Newhart
Bernard
Eva Gabor
Miss Bianca
Geraldine Page
Madame Medusa
Joe Flynn
Mr. Snoops
Jeanette Nolan
Ellie Mae
Pat Buttram
Luke
Jim Jordan
Orville
John McIntire
Rufus
Michelle Stacy
Penny
Bernard Fox
The Chairman
Larry Clemmons
Gramps
James MacDonald
Evinrude
George Lindsey
Rabbit
Bill McMillian
TV Announcer
Dub Taylor
Digger
John Fiedler
Owl
Ruth Buzzi
German Mouse
Robie Lester
Miss Bianca
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