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Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Cal Tech in Pasadena, California. They are colleagues, best friends, and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented, deeply eccentric, and non-conventional ways. They are also friends with their Cal Tech colleagues mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with women. When Penny, a pretty woman and an aspiring actress from Omaha, moves into the apartment across the hall from Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend.
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?
. Johnny Galecki
Leonard Hofstadter
Jim Parsons
Sheldon Cooper
Kaley Cuoco
Penny
Simon Helberg
Howard Wolowitz
Kunal Nayyar
Raj Koothrappali
Melissa Rauch
Bernadette Rostenkowski
Mayim Bialik
Amy Farrah Fowler
Kevin Sussman
Stuart Bloom
Carol Ann Susi
Debbie Wolowitz
John Ross Bowie
Barry Kripke
Laura Spencer
Emily Sweeney
Wil Wheaton
Wil Wheaton
Brian George
Dr. V.M. Koothrappali
Christine Baranski
Dr. Beverly Hofstadter
Brian Posehn
Bert Kibbler
Laurie Metcalf
Mary Cooper
Joshua Malina
President Siebert
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