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The cartoon follows roughly the same plot as the films The Toxic Avenger and its two succeeding sequels. A complete and hopeless nerd, Melvin, falls into toxic waste and becomes Toxie, a hideously deformed mutant of superhuman size and strength. Teaming with other mutants, No-Zone (whose power comes from radioactive sneezes), Major Disaster (he can control plants), Head-banger (Fender, a singing telegram delivery surfer-type, and Dr. Bender, a stereotype mad scientist, fused together - a hybrid character based on the Siamese twins in "Tromas War") and Junkyard, a dog/hobo hybrid, to become The Toxic Crusaders! Together they fight crime in every sense of the word and finally turn their attention on the Apolalypse Inc. of the movies Toxic Avenger Parts II & III, although in the series the chairman is an alien as opposed to Satan. The series follows the attempts of the crusaders to fight crime and be environmentally safe.
After years of silence from the Apocolypse INC (from part 2 and 3 of the Toxic Avenger seriers), Apocolypse INC returns to Tromaville under new management, instead of a demon, its an alien from the planet Smogulla known as Dr.Killemoff. Toxie has too battle Apocolypse once more to protect his hometown from the evil spage doers and the fat and corrupted Mayor. But he wont have to do it alone as a group of other mutant superheros join him in the fight, NoZone, Junkyard, Headbanger, Major Disaster and Toxie become THE TOXIC CRUSADERS.
. Gregg Berger
Mona
Susan Blu
Dr. Killemoff
Rodger Bumpass
No-Zone
Paul Eiding
Major Disaster
Ed Gilbert
Mayor Grody
John Mariano
Bonehead
Chuck McCann
Mrs. Junko
Hal Rayle
Yvonne
Susan Silo
Psycho
Kath Soucie
Junkyard
Michael J. Pollard
Self
Patric Zimmerman
Lloyd Kaufman
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