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The Harper brothers Charlie and Alan are almost opposites but form a great team. They have little in common except their dislike for their mundane, maternally cold and domineering mother, Evelyn. Alan, a compulsively neat chiropractor and control-freak, is thrown out by his manipulative wife Judith who nevertheless gets him to pay for everything and do most jobs in the house. Charlie is a freelance jingle composer and irresistible Cassanova who lives in a luxurious beach-house and rarely gets up before noon. Charlie "temporarily" allows Alan and his son Jake, a food-obsessed, lazy kid who shuttles between his parents, to move in with them after Alans separation/divorce. The sitcom revolves around their conflicting lifestyles, raising Jake (who has the efficient, caring dad while having a ball with his fun-loving sugar uncle who teaches him boyish things), and bantering with Evelyn and various other friends and family. Other fairly regular characters include Charlies cleaning lady Berta and his rich, self-confessed stalker neighbor Rose who often sneaks in to spy on Charlie.
After the death of his brother, Alan Harper meets and befriends a lonely young man named Walden Schmidt who turns out to be a billionaire. Unable to afford his brothers home, Alan sells Walden the house, and as a way of showing his gratitude, Walden allows Alan and his son Jake to move in with him.
. Jon Cryer
Alan Harper
Ashton Kutcher
Walden Schmidt
Angus T. Jones
Jake Harper
Conchata Ferrell
Berta
Charlie Sheen
Charlie Harper
Holland Taylor
Evelyn Harper
Marin Hinkle
Judith Harper
Melanie Lynskey
Rose
Courtney Thorne-Smith
Lyndsey Mackelroy
Jennifer Taylor
Chelsea
Ryan Stiles
Dr. Herb Melnick
Amber Tamblyn
Jenny Harper
Sophie Winkleman
Zoey
April Bowlby
Kandi
Graham Patrick Martin
Eldridge Mackelroy
Jane Lynch
Dr. Linda Freeman
Judy Greer
Bridget Schmidt
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